Part I. Introduction.- Statement of Purpose.- The Burden of Chronic Disease and the Role of Lifestyle Medicine.- Translating Knowledge and Implementing a Successful Lifestyle Medicine Center.- Part II. Concepts.- Implementation Science Across Lifestyle Medicine Interventions.- Models for Caring for Patients with Complex Lifestyle, Medical, and Social Needs.- The Role of Physical Infrastructure on Health and Well-being.- Preventive Medicine and Problem Solving in Populations.- Clinical Service Line Strategies in Lifestyle Medicine.- Business Plans for a Lifestyle Medicine Center.- Immersive Physical Environment.- Immersive Non-Physical Environment.- Planning, Constructing, and Operating a Clinic Gym.- Wearable Technologies in Lifestyle Medicine.- Guidelines for Developing Patient Educational Materials.- Implementing Behavioral Medicine in a Lifestyle Medicine Practice.- The Role of the Registered Dietitian.- Nutritionist in a Lifestyle Medicine Program.- Inter-professional Care: Integration with Exercise Physiologists.- The Inpatient Lifestyle Medicine Consultation Service.- Transcultural Lifestyle Medicine.- Spirituality.- Community Engagement to Improve Health.- Conducting Epidemiological Research and Clinical Trials in a Lifestyle Medicine Program.- Part III. Case Studies.- Lifestyle Medicine Centers.- Rippe Lifestyle Institute.- Northwestern Medicine Center for Lifestyle Medicine Lifestyle Medicine Center for Brain Aging and Neurodegenerative Diseases.- The Marie-Josée and Henry R. Kravis Center for Clinical Cardiovascular Health at Mount Sinai Heart.- Building a Prostate Cancer Lifestyle Medicine Program.- University of Arizona Center for Integrative Medicine.- Survey of International Centers that Incorporate Lifestyle Medicine.- Synthesis.